Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. (June 2018)

• Record Type: Journal Article
• Authors: Chen, Yao; Wang, Yingcan; Ding, Guodong; Tian, Ying; Zhou, Zhijun; Wang, Xiumin; Shen, Lixiao; Huang, Hong
• Is Part Of: Environment international. Volume 115(2018)
• Page Start: 410
• Page End: 416
• Publication Date: 2018-06
• Subjects: Bisphenol A -- Idiopathic central precocious puberty -- Urine -- Girl -- China; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.02.041
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Bisphenol A (BPA) is a well-known and widely used endocrine disrupter, but data on its association with childhood reproductive development are limited. Objectives: We investigated the possible relationship between exposure to BPA and idiopathic central precocious puberty (ICPP) in school-aged girls. Methods: We conducted a 1:1 matched case-control study in Shanghai, China, between July 2011 and September 2012. This study included 136 school-aged (6 to 9 years old) girls diagnosed with ICPP and 136 controls matched for age and body mass index (BMI). We measured the urinary BPA concentrations of all the girls and examined the association with odds of having ICPP. Laboratory examinations including serum estradiol (E2) levels, basal and gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels, bone ages (BA), and uterine and ovarian sizes were conducted in the ICPP girls. Results: Median concentrations of urinary BPA in the ICPP and control groups were 6.35 and 1.17 μg/g creatinine (Cr), respectively (p < 0.001). After adjustment for confounders, compared to those with the lowest concentrations of BPA, the highest concentrations were associated with a 9.08-fold increased odds of having ICPP [odds ratio (OR) = 9.08, (95% confidence interval (CI): 2.83–29.15)]. In the ICPP group, modest negative correlation was present between urinary BPA concentrations (μg/g Cr) and peak FSH levels [β = −0.090 (95% CI: −0.178, −0.003), p = 0.044]. Conclusions: Our findings suggest that BPA exposure is associated with increased odds of having ICPP in school-aged girls, and the potential mechanism may be attributable to the relatively low FSH levels. Graphical abstract: Unlabelled Image Highlights: BPA is widespread among children in China and around the world. Animal studies showed reproductive effects, but it is unclear in humans. We examined the relationship of BPA exposure and ICPP in school-aged girls. BPA exposure is associated with an elevated risk of ICPP in school-aged girls. The potential mechanism may be attributable to the relatively low FSH levels.