Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside. (January 2020)

• Record Type: Journal Article
• Authors: Lan, Xu; Zhao, Junnan; Zhang, Ying; Chen, Yao; Liu, Yue; Xu, Fengqin
• Is Part Of: Pharmacological research. Volume 151(2020)
• Publication Date: 2020-01
• Subjects: 12/15-LOX 12/15-lipoxygenase -- α-SMA α-smooth muscle actin -- β2AR β2-adrenoceptor -- AA arachidonic acid -- Acc acetyl CoA carboxylase -- ACE angiotensin converting enzyme -- Acox1 acyl CoA oxidase -- ADMA asymmetric dimethylarginine -- AGE advanced glycation end products -- AIF apotosis-inducing factor -- AKT protein kinase B -- ALT alanine aminotransferase -- AMY amylase -- AST aspartate aminotransferase -- Bcl-2 B-cell lymphoma 2 -- BNP brain natruretic peptide -- BUN blood urea nitrogen -- CAT catalase -- CCL4 carbon tetrachloride -- CD cluster of differentiation -- CK-MB creatine kinase isoenzyme MB -- COL pro‐collagen -- COX-2 cyclooxygenase-2 -- cPLA2 cytosolic phospholipase A2 -- Cpt1a carnitine palmitoyltransferase 1A -- Cr creatinine -- CREB cyclic adenosine monophosphate (cAMP) response element-building -- CRP C-reactive protein -- CTGF connective tissue growth factor -- cTn-I cardiac troponin I -- D-GalN D-galactosamine -- DDAH dimethylarginine dimethylaminohydrolase -- DHPR dihydropyridine receptor -- DM diabetes mellitus -- DSS dextran sodium sulfate -- ENaC epithelial Na+channel -- ERK extracellular signal-regulated kinases -- ET endothelin -- Fas fatty acid synthase -- FFA free fatty acid -- FinS fasting serum insulin -- FMT fibroblast-to-myofibroblast transformation -- FN fibronectin -- GIR glucose infusion rate -- GLP-1 glucagon-like peptide-1 -- GLUT glucose transporter -- GSH-Px glutathione peroxidase -- GSK-3β glycogen synthase kinase-3 beta -- HDL-c high density lipoprotein cholesterol -- HIF hypoxia-inducible factor -- HMGB1 high mobility group box-1 -- HO heme oxygenase -- HSF heat shock factor -- Hsp heat shock protein -- Hyp hydroxyproline -- IκB inhibitor of nuclear factor-κB -- ICAM intercellular adhesion molecule -- ICR institute of cancer research -- IFN interferon -- i.g. intragastric -- IL interleukin -- i.m. intramuscular injection -- iNOS inositol -- i.p. intraperitoneal injection -- i.v. intravenous injection -- ivgtt intravenously guttae -- JAK janus kinase -- JNK c-Jun N-terminal kinase -- KSPR KH-type splicing regulatory protein -- LD50 median lethal dose -- LDH lactate dehydrogenase -- LDL-c low density lipoprotein cholesterol -- LPO lipid peroxides -- LPS lipopolysaccharide -- MAPK mitogen-activated protein kinase -- MCL-1 Myeloid cell leukemia-1 -- MCP monocyte chemotactic protein -- MDA malondialdehyde -- MMP matrix metalloproteinase -- MPO myeloperoxidase -- mRNA messenger ribonucleic acid -- MTTP microsomal triglyceride transfer protein -- MyD88 myeloid differentiation factor 88 -- NEFA non-esterified fatty acid -- NF nuclear factor -- NMDA N-methyl-d- aspartate -- NO nitric oxide -- Nrf nuclear factor erythroid 2-related factor -- p-IκB phosphorylation inhibitor of nuclear factor-κB -- PGE2 prostaglandin E2 -- p.o. per os -- p38 MAPK p38 mitogen-activated protein kinase -- PARP cleavage of poly (ADP-ribose) polymerase -- PASI Psoriasis Area and Severity Index -- PGI prostaglandin -- PI3K phosphoinositide 3-kinases -- Pparα peroxisome proliferator activated receptor alpha -- PRISMA Preferred Reporting Items for Systematic Reviews and Meta-analyses -- RNA ribonucleic acid -- ROS reactive oxygen species -- Scr serum creatinine -- SD Sprague-Dawley -- SERCA2a SR-Ca2+ ATPase -- Smad mothers against decapentaplegic -- SOD superoxide dismutase -- Srebf1 sterol regulatory element binding transcription factor 1 -- STAT signal transducer -- STZ streptozotocin -- T-AOC total antioxidant capacity -- TC total cholesterol -- TCM traditional Chinese medicine -- TG triglyceride -- TGF transforming growth factor -- Th T helper -- TIMP tissue inhibitor of metalloproteinase -- TLR toll-like receptor -- TNBS trinitrobenzene sulfonic acid -- TNF tumor necrosis factor -- Treg regulatory T -- VCAM vascular cell adhesion molecule -- VEGF vascular endothelial growth factor; Oxymatrine (PubChem CID: 114850); Oxymatrine -- Inflammation -- Cancer -- Apoptosis -- Fibrosis -- Nociception; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.104541
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Oxymatrine is a quinazine alkaloid extracted from Sophora flavescens with various therapeutic effects such as organ- and tissue-protective, anti-inflammatory, anti-cancer, and anti-viral effects. In this review, we summarize the protective effects of oxymatrine on damaged organs and tissues by analyzing both in vivo and in vitro studies. The mechanisms of protective effects of oxymatrine are mainly related to its anti-inflammatory, anti-oxidative stress, anti- or pro-apoptotic, anti-fibrotic, metabolism-regulation, and anti-nociceptive functions. In addition, a variety of signal pathways, cells, and molecules are influenced by oxymatrine, and by these comprehensive actions, maximum therapeutic effects can be achieved. Furthermore, we summarize the protective effects in clinical studies and adverse effects of oxymatrine. It is believed that through more in-depth animal experiments and standardized clinical research, oxymatrine holds a bright future in the process of organ and tissue protection and has a significant therapeutic promise to translate from bench to bedside.