Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood. Issue 4 (April 1978)

• Record Type: Journal Article
• Authors: Hann, I M; Evans, D I; Marsden, H B; Jones, P M; Palmer, M K
• Is Part Of: Journal of clinical pathology. Volume 31:Issue 4(1978)
• Page Start: 313
• Page End: 315
• Publication Date: 1978-04
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.31.4.313
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary myelofibrosis (SMF) was present at diagnosis in 57% of the cases. It was not statistically significantly related to the prognosis or course of the disease. Thus, although trephine biopsy occasionally provided useful information in different diagnosis and when aspiration was difficult, it provided little information of use for management.