Diagnostic concordance of reporting lymphovascular invasion in breast cancer. Issue 9 (29th March 2018)

• Record Type: Journal Article
• Authors: Rakha, Emad A; Abbas, Areeg; Pinto Ahumada, Pablo; ElSayed, Maysa E; Colman, Derek; Pinder, Sarah E; Ellis, Ian O
• Is Part Of: Journal of clinical pathology. Volume 71:Issue 9(2018)
• Page Start: 802
• Page End: 805
• Publication Date: 2018-03-29
• Subjects: interobserver agreement -- lymphovascular invasion -- breast cancer; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2017-204981
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Aims: This study aims to assess the diagnostic agreement of lymphovascular invasion (LVI) in invasive breast cancer (BC). Methods: Data on LVI were collected from the UK National Health Service Breast Screening Programme pathology external quality assurance scheme database. 101 BCs assessed over a 10-year period (2004–2014) were included. Cases were scored by an average of 600 pathologists. Three H&E stained slides from each case were reviewed by three pathologists and additional variables were evaluated. Results: In the whole series, the overall κ value was 0.4 (range 0.26–0.53). On review, LVI was detected in all three slides in 20 cases (20%), in two slides in 12 cases and in one of the three slides in 9 cases and was not seen in 60 cases. For concordance analysis, the first and last groups were used to represent cases with definite (LVI+) and absent LVI (LVI–), respectively. In the LVI+group (n=20), the level of agreement ranged from 0.54 to 0.99 (median 0.86). In the LVI– group (n=60), the level of agreement ranged from 0.52 to 1.00 (median 0.93), with 44% of cases showing interobserver concordance of >95%. There was a correlation between increasing number of involved lymphovascular spaces in the section and higher LVI reporting concordance. Some degree of retraction/fixation artefacts was observed in 35% of cases; this was associated with a lower concordance rate. Conclusions: The concordance of reporting LVI is variable. Cases without LVI and those with multiple involved vessels are likely to have the highest concordance and the highest detection rates.