Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?. Issue 3 (9th April 2008)

• Record Type: Journal Article
• Authors: Lucia, A; De La Rosa, A; Silván, M Avila; López-Mojares, L M; Boraita, A; Pérez, M; Foster, C; García-Castro, J; Ramirez, M
• Is Part Of: British journal of sports medicine. Volume 43:Issue 3(2009)
• Page Start: 221
• Page End: 223
• Publication Date: 2008-04-09
• Subjects: Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2007.044693
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53–76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.