Intestinal goblet cell autoantibody associated enteropathy. Issue 8 (30th July 2003)

• Record Type: Journal Article
• Authors: Hori, K; Fukuda, Y; Tomita, T; Kosaka, T; Tamura, K; Nishigami, T; Kubota, A; Shimoyama, T
• Is Part Of: Journal of clinical pathology. Volume 56:Issue 8(2003)
• Page Start: 629
• Page End: 630
• Publication Date: 2003-07-30
• Subjects: autoimmune enteropathy -- collagenous enterocolitis -- collagenous colitis -- refractory sprue -- goblet cell autoantibodies; AE, autoimmune enteropathy -- CE, collagenous enterocolitis -- IE, intestinal goblet cell autoantibody associated enteropathy -- IGA, intestinal goblet cell autoantibodies -- TPN, total parenteral nutrition; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.56.8.629
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : This report describes a case of refractory enteropathy with circulating intestinal goblet cell autoantibodies (IGA). A 19 year old man with hyperthyroidism had suffered from protracted diarrhoea for nearly 10 years. Histological examination showed evidence of collagenous enterocolitis. The diarrhoea did not improve despite fasting under total parenteral nutrition. An immunofluorescence assay demonstrated IGA without anti-enterocyte autoantibodies, the hallmark of autoimmune enteropathy, although other criteria were fulfilled. None of 109 controls, including 55 cases of inflammatory bowel disease and one of lymphocytic colitis, had IGA. This case is considered to be a variant of autoimmune enteropathy, and might be a distinct entity.