Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy. (August 2021)

• Record Type: Journal Article
• Authors: Yang, Nan; Guo, Heng; Cao, Changyu; Wang, Xiaorui; Song, Xuejiao; Wang, Wenjun; Yang, Dongliang; Xi, Lei; Mou, Xiaozhou; Dong, Xiaochen
• Is Part Of: Biomaterials. Volume 275(2021)
• Publication Date: 2021-08
• Subjects: Infection-microenvironment responsive -- Methicillin-resistant Staphylococcus aureus -- Synergistic antibacterial therapies -- Cuprous oxide; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2021.120918
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Subcutaneous abscesses caused by drug-resistant bacteria pose huge challenges to human health. The design of infection microenvironment-activated biomaterials has an advantage for the diagnosis and treatment of infective diseases due to its high specificity and efficiency. Herein, a novel theranostic platform based on Cu2 O nanoparticles (NPs) is successfully constructed via a simple, fast and low-cost approach. The Cu2 O NPs exhibit high sensitivity to overexpressed H2 S and H2 O2 in the bacterial infection microenvironment. After in situ injection, the Cu2 O NPs will rapidly react with the endogenous H2 S to generate Cu9 S8 NPs, which exhibits high absorbance in the second near-infrared (NIR-II) biowindow. The Cu9 S8 NPs serving as NIR-II photoacoustic contrast agents can exactly distinguish between inflammatory and normal tissues. With the guidance of NIR-II photoacoustic imaging (PAI), H2 S-activated photothermal antibacterial therapy (PTAT) can realize excellent antibacterial performance under 1060 nm laser irradiation. Meanwhile, the Cu2 O NPs can effectively catalyze H2 O2 at the site of inflammation to produce hydroxyl radicals with strong antibacterial property via Fenton-like reaction, resulting in the damage of bacterial cell membrane. Furthermore, the application of Cu2 O NPs can enhance epidermic migration and facilitate the re-epithelialization of the infected skin. In vivo experiment shows that 97.9% methicillin-resistant Staphylococcus aureus are eliminated by the synergistic PTAT and chemodynamic antibacterial therapy.