THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes. (11th November 2019)

• Record Type: Journal Article
• Authors: Alexander, Stephen P H; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair; Peters, John A; Veale, Emma L; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Pawson, Adam J; Sharman, Joanna L; Southan, Christopher; Davies, Jamie A
• Other Names: Beuve Annie investigator.; Boison Detlev investigator.; Brouckaert Peter investigator.; Burnett John C investigator.; Burns Kathryn investigator.; Dessauer Carmen investigator.; Friebe Andreas investigator.; Garthwaite John investigator.; Gertsch Jürg investigator.; Helsby Nuala investigator.; Izzo Angelo A investigator.; Koesling Doris investigator.; Kuhn Michaela investigator.; Ostrom Rennolds investigator.; Papapetropoulos Andreas investigator.; Potter Lincoln R investigator.; Pyne Nigel J investigator.; Pyne Susan investigator.; Russwurm Michael investigator.; Schmidt Harald HHW investigator.; Seifert Roland investigator.; Stasch Johannes‐Peter investigator.; Szabo Csaba investigator.; van der Stelt Mario investigator.; van der Vliet Albert investigator.; Watts Val investigator.
• Is Part Of: British journal of pharmacology. Volume 176(2019)Supplement 1
• Page Start: S297
• Page End: S396
• Publication Date: 2019-11-11
• Subjects: Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.14752
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14752 . Enzymes are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.