AB0657 25 hydroxy D vitamin status in patients with primary sjÖgren's disease. (23rd January 2014)

• Record Type: Journal Article
• Authors: Kiss, E.; Bazso, A.; Meszaros, J.; Nagy, E.; Lelkes, G.; Poor, G.
• Is Part Of: Annals of the rheumatic diseases. Volume 71(2012)Supplement 3
• Page Start: 676
• Page End: 676
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2012-eular.657
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Primary Sjogren's syndrome (pSS) is characterised by diminished exocine glandular functions caused by autoimmune epithelitis due to dysregulated immune response. Low vitamin D level might be one of its etiologic factors. Objectives: The aim of this cross-sectional study was to evaluate 25 hydroxy D vitamin status in a cohort of Hungarian patients with pSS. Methods: European-American consensus criteria were used to identify pSS patients. 25-hydroxyvitamin D (25OH D) was measured by a direct competitive chemiluminescent immunoassay. Anti-SS-A, anti-SS-B and rheumatoid factor (RF) were assessed with routine laboratory methods. Appropriate statistical tests were used to analyse association between 25OH D level and clinical as well as laboratory parameters. Results: The mean ages of the 54 pSS female patients was 58.6±13.92 years. Anti- SS-A, anti-SS-B and RF was present in 33, 26 and 17 patients. Arthritis, vasculitis, CNS or PNS manifestations and autoimmune thyreoiditis occurred in 37, 10, 8, 14 and 17 patients, respectively. The concentration of 25OH D (mean±SD) was 76.86±42.6 nmol/L. As much as 35.19% were vitamin D insufficient and 16.66% deficient. These groups were definied based on 25OH D concentration between 37.5 and 75L or <37.5 nmol/L. There was a weak but significant correlation between vitaminD concentration and the age of patients (p=0.026, r=-0.303, Spearman correlation), but no correlation was found with other laboratory parameters. Chi2 test revealed association between vitamin D level groups and the presence of RF (p=0.047) as well as autoimmune thyreoiditis (p=0.009). Conclusions: Reduced vitamin D level might contribute to the pathogenesis of primary Sjogren's disease, but until now only a few data are available. Further prospective studies are required in larger cohort of patients in comparison with other autoimmune diseases and healthy population. References: CantornaMT: Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med 2000;223:230-3. Cutolo M: Vitamin D and autoimmune rheumatic diseases. Rheumatology (Oxford) 2009; 48: 210-212. Borba VZ, Vieira JGH, Kasamatsu T, et al. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporosis 2009; 3: 427-433. Szodoray P, Tarr T, Bazso A, et al: The immunopathological role of vitamin D in patients with SLE: data from a single centre registry in Hungary. Scand J Rheumatol. 2011 Mar;40(2):122-6. Amital H, Szekanecz Z, Szücs G, et al: Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheum Dis. 2010 Jun;69(6):1155-7. Disclosure of Interest: None Declared