Glutathione peroxidase in early and advanced Parkinson's disease. Issue 8 (August 1991)

• Record Type: Journal Article
• Authors: Johannsen, P; Velander, G; Mai, J; Thorling, E B; Dupont, E
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 54:Issue 8(1991)
• Page Start: 679
• Page End: 682
• Publication Date: 1991-08
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.54.8.679
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : A defective antioxidant scavenging system plays a major role in one of the theories of the pathogenesis of Parkinson's disease. The aim of this study was to investigate whether there is a general difference in antioxidant activity between early and advanced cases of Parkinson's disease. Twenty five recently diagnosed patients, without any clinical fluctuations (group A), and 25 patients in a late phase of the disease with severe fluctuations in response to levodopa therapy (group B) were included in the study. Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A. Regression analyses in groups A and B showed significant correlation between glutathione peroxidase and duration of disease, but not between glutathione peroxidase and age of patients.