Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus. Issue 3 (1st March 2000)

• Record Type: Journal Article
• Authors: Ichiishi, E; Yoshikawa, T; Kogawa, T; Yoshida, N; Kondo, M
• Is Part Of: Gut. Volume 46:Issue 3(2000)
• Page Start: 432
• Page End: 434
• Publication Date: 2000-03-01
• Subjects: cancer -- gastric -- oesophageal -- stomach -- granulocyte colony stimulating factor -- receptor; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.46.3.432
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.