Fatigue in chronic cholestasis. Issue 4 (11th March 2004)

• Record Type: Journal Article
• Authors: Milkiewicz, P; Heathcote, E J
• Is Part Of: Gut. Volume 53:Issue 4(2004)
• Page Start: 475
• Page End: 477
• Publication Date: 2004-03-11
• Subjects: fatigue -- cholestasis -- primary biliary cirrhosis -- magnetisation transfer ratio -- manganese; SLE, systemic lupus erythematosus -- PBC, primary biliary cirrhosis -- Mn, manganese -- 1H MRS, proton magnetic resonance spectroscopy -- MTR, magnetisation transfer ratio -- PSE, portosystemic encephalopathy -- CNS, central nervous system -- GP, globus pallidus; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.2003.025155
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Fatigue is probably the most intriguing symptom affecting patients with chronic cholestatic disorders, in particular those with primary biliary cirrhosis. It is postulated that fatigue in patients with primary biliary cirrhosis may be associated with morphological abnormalities of the central nervous system secondary to accumulation of manganese. However, we are still far from understanding this complex issue.