PFM.45 Sacrococcygeal Teratoma: prenatal diagnosis, prevalence, and survival in an 18 year population-based cohort from an NHS region. (9th June 2014)

• Record Type: Journal Article
• Authors: Tonks, AM; Ayed, A; Lander, A; Kilby, MD
• Is Part Of: Archives of disease in childhood. Volume 99:Supplement 1(2014)
• Page Start: A96
• Page End: A97
• Publication Date: 2014-06-09
• Subjects: Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/archdischild-2014-306576.275
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Background: Sacrococcygeal Teratoma (SCT) is a rare tumour that is 'benign' but carries with it a variable prognosis for survival. Methods: Suspected and confirmed cases presenting before 1 year of age were selected using a regional, population-based, multiple-source, anomaly register from a birth cohort of 1, 215, 140. Suspected cases were analysed separately as false positive ultrasound diagnoses. Results: 35 confirmed cases of SCT delivered between 1995–2012. Total and live births prevalences were 0.29 per 10, 000 births (95% CI 0.19–0.38) and 0.21 per 10, 000 live births (95% CI 0.13–0.29). Sex ratio (M:F) was 1:2.4. 22 cases were diagnosed prenatally (median gestation 20 +1 weeks), the sensitivity of antenatal ultrasound was 62.3% (95% CI 46.8–78.9). The uptake of termination following prenatal diagnosis was 31.2%. There were 6 antenatal false positives; therefore the positive predictive value of antenatal ultrasound was 78.6% (95% CI 63.4–93.8). The confirmed anomalies for the false positives cases were spinal and neural tube defects. Histopathology was ascertained in 27 cases at surgery/postmortem, the tumours were benign (52%), immature (37%), and mixed (11%). Altman staging (final confirmed) was recorded in 25 cases; the majority of cases were stage II (56.0%). A comparison of prenatal ultrasound and MRI was made. The survival to 1 year of age amongst liveborn cases (n = 25) was 84.0% (95% CI 69.6–98.4), and amongst all cases with spontaneous outcomes (excludes terminations) was 75.0% (95% CI 59.0–91.0). Conclusion: This population-based series indicates that prenatal ultrasound is relatively sensitive and specific in diagnosing SCT. The survival rate in liveborn cases is good.