Aortic valve prosthesis–patient mismatch and exercise capacity in adult patients with congenital heart disease. Issue 2 (23rd November 2015)

• Record Type: Journal Article
• Authors: van Slooten, Ymkje J; van Melle, Joost P; Freling, Hendrik G; Bouma, Berto J; van Dijk, Arie PJ; Jongbloed, Monique RM; Post, Martijn C; Sieswerda, Gertjan T; Huis in 't Veld, Anna; Ebels, Tjark; Voors, Adriaan A; Pieper, Petronella G
• Is Part Of: Heart. Volume 102:Issue 2(2016)
• Page Start: 107
• Page End: 113
• Publication Date: 2015-11-23
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2015-308013
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To report the prevalence of aortic valve prosthesis–patient mismatch (PPM) in an adult population with congenital heart disease (CHD) and its impact on exercise capacity. Adults with congenital heart disease (ACHD) with a history of aortic valve replacement may outgrow their prosthesis later in life. However, the prevalence and clinical consequences of aortic PPM in ACHD are presently unknown. Methods: From the national Dutch Congenital Corvitia (CONCOR) registry, we identified 207 ACHD with an aortic valve prosthesis for this cross-sectional cohort study. Severe PPM was defined as an indexed effective orifice area ≤0.65 cm 2 /m 2 and moderate PPM as an indexed orifice area ≤0.85 cm 2 /m 2 measured using echocardiography. Exercise capacity was reported as percentage of predicted exercise capacity (PPEC). Results: Of the 207 patients, 68% was male, 71% had a mechanical prosthesis and mean age at inclusion was 43.9 years ±11.4. The prevalence of PPM was 42%, comprising 23% severe PPM and 19% moderate PPM. Prevalence of PPM was higher in patients with mechanical prostheses (p<0.001). PPM was associated with poorer exercise capacity (mean PPEC 84% vs 92%; p=0.048, mean difference =−8.3%, p=0.047). Mean follow-up was 2.6±1.1 years during which New York Heart Association (NYHA) class remained stable in most patients. PPM showed no significant effect on death or hospitalisation during follow-up (p=0.218). Conclusions: In this study we report a high prevalence (42%) of PPM in ACHD with an aortic valve prosthesis and an independent association of PPM with diminished exercise capacity.