Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants. Issue 4 (April 1978)

• Record Type: Journal Article
• Authors: Shakir, R A; Behan, P O; Dick, H; Lambie, D G
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 41:Issue 4(1978)
• Page Start: 307
• Page End: 311
• Publication Date: 1978-04
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.41.4.307
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.