Education modulates brain maintenance in presymptomatic frontotemporal dementia. Issue 10 (10th June 2019)

• Record Type: Journal Article
• Authors: Gazzina, Stefano; Grassi, Mario; Premi, Enrico; Cosseddu, Maura; Alberici, Antonella; Archetti, Silvana; Gasparotti, Roberto; Van Swieten, John; Galimberti, Daniela; Sanchez-Valle, Raquel; Laforce, Robert Jr; Moreno, Fermin; Synofzik, Matthis; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Vandenberghe, Rik; Finger, Elizabeth; Tagliavini, Fabrizio; de Mendonça, Alexandre; Santana, Isabel; Butler, Christopher R; Ducharme, Simon; Gerhard, Alex; Danek, Adrian; Levin, Johannes; Otto, Markus; Frisoni, Giovanni; Sorbi, Sandro; Padovani, Alessandro; Rohrer, Jonathan D; Borroni, Barbara;
• Other Names: author non-byline.; Almeida Maria Rosario author non-byline.; Anderl-Straub Sarah author non-byline.; Andersson Christin author non-byline.; Antonell Anna author non-byline.; Arighi Andrea author non-byline.; Balasa Mircea author non-byline.; Barandiaran Myriam author non-byline.; Bargalló Nuria author non-byline.; Bartha Robart author non-byline.; Bender Benjamin author non-byline.; Benussi Luisa author non-byline.; Binetti Giuliano author non-byline.; Black Sandra author non-byline.; Bocchetta Martina author non-byline.; Borrego-Ecija Sergi author non-byline.; Bras Jose author non-byline.; Bruffaerts Rose author non-byline.; Caroppo Paola author non-byline.; Cash David author non-byline.; Castelo-Branco Miguel author non-byline.; Convery Rhian author non-byline.; Cope Thomas author non-byline.; Arriba María de author non-byline.; Fede Giuseppe Di author non-byline.; Díaz Zigor author non-byline.; Dick Katrina M author non-byline.; Duro Diana author non-byline.; Ferreira Carlos author non-byline.; Ferreira Catarina B author non-byline.; Flanagan Toby author non-byline.; Fox Nick author non-byline.; Freedman Morris author non-byline.; Fumagalli Giorgio author non-byline.; Gabilondo Alazne author non-byline.; Gauthier Serge author non-byline.; Ghidoni Roberta author non-byline.; Giaccone Giorgio author non-byline.; Gorostidi Ana author non-byline.; Greaves Caroline author non-byline.; Guerreiro Rita author non-byline.; Heller Carolin author non-byline.; Hoegen Tobias author non-byline.; Indakoetxea Begoña author non-byline.; Jelic Vesna author non-byline.; Jiskoot Lize author non-byline.; Karnath Hans-Otto author non-byline.; Keren Ron author non-byline.; Leitão Maria João author non-byline.; Lladó Albert author non-byline.; Lombardi Gemma author non-byline.; Loosli Sandra author non-byline.; Maruta Carolina author non-byline.; Mead Simon author non-byline.; Meeter Lieke author non-byline.; Miltenberger Gabriel author non-byline.; Minkelen Rick van author non-byline.; Mitchell Sara author non-byline.; Nacmias Benedetta author non-byline.; Neason Mollie author non-byline.; Nicholas Jennifer author non-byline.; Öijerstedt Linn author non-byline.; Olives Jaume author non-byline.; Panman Jessica author non-byline.; Papma Janne author non-byline.; Patzig Maximilian author non-byline.; Pievani Michela author non-byline.; Pijnenburg Yolande author non-byline.; Prioni Sara author non-byline.; Prix Catharina author non-byline.; Rademakers Rosa author non-byline.; Redaelli Veronica author non-byline.; Rittman Tim author non-byline.; Rogaeva Ekaterina author non-byline.; Rosa-Neto Pedro author non-byline.; Rossi Giacomina author non-byline.; Rossor Martin author non-byline.; Santiago Beatriz author non-byline.; Scarpini Elio author non-byline.; Semler Elisa author non-byline.; Shafei Rachelle author non-byline.; Shoesmith Christen author non-byline.; Tábuas-Pereira Miguel author non-byline.; Tainta Mikel author non-byline.; Tang-Wai David author non-byline.; Thomas David L author non-byline.; Thonberg Hakan author non-byline.; Timberlake Carolyn author non-byline.; Tiraboschi Pietro author non-byline.; Vandamme Philip author non-byline.; Vandenbulcke Mathieu author non-byline.; Veldsman Michele author non-byline.; Verdelho Ana author non-byline.; Villanua Jorge author non-byline.; Wilke Carlo author non-byline.; Zetterberg Henrik author non-byline.; Zulaica Miren author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 90:Issue 10(2019)
• Page Start: 1124
• Page End: 1130
• Publication Date: 2019-06-10
• Subjects: frontotemporal dementia (FTD) -- brain reserve -- brain maintenance -- graph theory -- magnetic resonance imaging (MRI); Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2019-320439
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objective: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods: Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling. Results: Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers. Conclusions: This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.