Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. Issue 5 (29th April 2005)

• Record Type: Journal Article
• Authors: Abdollahi, M R; Gaunt, T R; Syddall, H E; Cooper, C; Phillips, D I W; Ye, S; Day, I N M
• Is Part Of: Journal of medical genetics. Volume 42:Issue 5(2005)
• Page Start: 396
• Page End: 401
• Publication Date: 2005-04-29
• Subjects: ACE, angiotensin converting enzyme -- AGT II, angiotensin II -- AGTR1, angiotensin II type I receptor -- AGTR2, angiotensin II type II receptor -- BMI, body mass index -- CAD, coronary artery disease -- DN, diabetic nephropathy -- HW, Hardy-Weinberg -- I/D, insertion/deletion -- K-EDTA, ethylenediaminetetra-acetic acid potassium salt -- LD, linkage disequilibrium -- OGTT, oral glucose tolerance test -- RAS, renin angiotensin system -- RNAbp, RNA-binding protein -- SNP, single nucleotide polymorphism -- UTR, untranslated region; ACE -- AGTR1 A1166C -- angiotensin II type I receptor -- metabolic and anthropometric traits; Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.2004.026716
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Background: The renin angiotensin system is important in the regulation of vascular tone and fluid and electrolyte balance. The angiotensin converting enzyme gene ( ACE ) genotype has been shown to affect exercise response and glucose load response dependent on birth weight. Angiotensin II type I receptor ( AGTR1 ) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated. Method: AGTR1 A1166C was genotyped by allele specific PCR in 378 individuals from Hertfordshire, UK, who had been characterised for metabolic syndrome traits. Results: Genotype counts were: AA, 183; AC, 170; CC, 25, consistent with Hardy-Weinberg equilibrium. The CC genotype was associated with significantly lower body mass index (by 1.7 units) in men (p = 0.03), and the same magnitude effect in women with significant lower weight in both genders (p = 0.01), also lower waist circumference and waist-hip ratio (p = 0.01) in men, with a trend for lower waist circumference in women also. Additionally, the CC genotype and/or C allele was associated with lower fasting glucose and insulin, and 30 and 120 min glucose in men (respectively, p = 0.08, 0.04, 0.01, 0.06). Lower means of systolic blood pressure, pulse pressure, cholesterol, and fasting triglyceride were also observed for the CC genotype in both genders though these were not statistically significant. Conclusions: The AGTR1 1166 CC genotype appears to predispose to favourable anthropometric and metabolic traits, relative to cardiovascular risk.