Analysis of the origin of Turner's syndrome using polymorphic DNA probes. Issue 3 (March 1991)

• Record Type: Journal Article
• Authors: Loughlin, S A; Redha, A; McIver, J; Boyd, E; Carothers, A; Connor, J M
• Is Part Of: Journal of medical genetics. Volume 28:Issue 3(1991)
• Page Start: 156
• Page End: 158
• Publication Date: 1991-03
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.28.3.156
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Thirty-four families with a child or fetus with Turner's syndrome were studied using a series of polymorphic DNA probes. Analysis of the origin of the normal X chromosome was possible in all cases. In 16 families with 45, X (four fetuses and 12 livebirths), the observed X was maternal in each case, indicating a preferential loss of the paternal sex chromosome at, or before, conception. In the remaining 18 families with a variety of karyotypes, but especially in those where the child had an isochromosome of Xq or a ring X, there was again a strong tendency for the normal X to be maternal. Analysis of parental ages was performed with known origin of each abnormality, but no evidence for an increased or decreased parental age effect was detected.