Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming. (2nd May 2021)

• Record Type: Journal Article
• Authors: Wang, Chao; Gong, Yufeng; Deng, Fuchang; Ding, Enmin; Tang, Jie; Codling, Garry; Challis, Jonathan K.; Green, Derek; Wang, Jing; Chen, Qiliang; Xie, Yuwei; Su, Shu; Yang, Zilin; Raine, Jason; Jones, Paul D.; Tang, Song; Giesy, John P.
• Is Part Of: Global change biology. Volume 27:Number 14(2021)
• Page Start: 3282
• Page End: 3298
• Publication Date: 2021-05-02
• Subjects: Arctic warming -- chronic temperature shifts -- dynamic alterations -- glycerolipids -- glycerophospholipids -- lipidomics -- machine learning; Climatic changes -- Environmental aspects -- Periodicals; Troposphere -- Environmental aspects -- Periodicals; Biodiversity conservation -- Periodicals; Eutrophication -- Periodicals; 551.5
• DOI: 10.1111/gcb.15638
• Languages: English
• ISSNs: 1354-1013

Abstract

Abstract: Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high‐resolution mass‐spectrometry‐based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species—Arctic char ( Salvelinus alpinus )—with a detailed multi‐tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One‐year‐old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup‐specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso‐GPs, and more ether‐GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight‐week‐old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near‐future warming. Abstract : Arctic warming poses a significant threat to populations of wildlife in the Arctic. In this study, we revealed several adaptive mechanisms of Arctic char lipidome in response to chronic temperature shifts. We demonstrated that Arctic char respond to increased temperatures with highly coordinated lipid regulations, including headgroup‐specific remodeling of acyl chain profile in glycerophospholipids and extensive alterations in membrane lipid composition. Moreover, triacylglycerol can serve as cache of fatty acids for membrane lipids remodeling during the thermal adaption process. However, 8‐week‐old Arctic char showed blunted responses to gradual temperature increases, implying an inability to adapt rapidly to a warmer environment.