Is saliva serology useful for the diagnosis of Helicobacter pylori?. Issue 1 (July 1996)

• Record Type: Journal Article
• Authors: Christie, J M; McNulty, C A; Shepherd, N A; Valori, R M
• Is Part Of: Gut. Volume 39:Issue 1(1996)
• Page Start: 27
• Page End: 30
• Publication Date: 1996-07
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.39.1.27
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : BACKGROUND: The Cortecs Diagnostics Helisal Assay test is a quantitative immunoassay for salivary IgG antibodies against Helicobacter pylori. Saliva can be obtained simply with the kit in the general practitioners surgery. AIMS: To compare the new saliva serological test for H pylori with 'gold standard' evidence of H pylori infection (antral biopsy specimens for histology, culture, and urease test) and a new serum serological test. PATIENTS: Eighty six unselected dyspeptic patients undergoing endoscopy. METHODS: Each patient provided saliva and serum before endoscopy for H pylori serology, which was compared against 'gold standard' evidence of infection. RESULTS: Thirty two patients were H pylori positive by the 'gold standard' tests. At a cut off value of 0.15 EU/ml the saliva test had a sensitivity of 88% and a specificity of 71%, with a negative predictive value of 90%. If patients who were taking omeprazole or had recent antibiotics are excluded, the sensitivity is unchanged but the specificity increases to 79%. The serum test had a similar sensitivity of 85% but better specificity of 78%. CONCLUSION: Serum testing remains the best serological test for H pylori in the hospital setting. Saliva testing may have a role in epidemiological studies and in screening dyspeptic patients in general practice, especially in children in whom venesection is more difficult.