Relation between aortic stiffness and coronary flow reserve in patients with coronary artery disease. Issue 6 (10th October 2005)

• Record Type: Journal Article
• Authors: Fukuda, D; Yoshiyama, M; Shimada, K; Yamashita, H; Ehara, S; Nakamura, Y; Kamimori, K; Tanaka, A; Kawarabayashi, T; Yoshikawa, J
• Is Part Of: Heart. Volume 92:Issue 6(2006)
• Page Start: 759
• Page End: 762
• Publication Date: 2005-10-10
• Subjects: 1VD, one vessel disease -- 2VD, two vessel disease -- 3VD, three vessel disease -- ba-PWV, brachial-ankle pulse wave velocity -- BP, blood pressure -- CAD, coronary artery disease -- CFR, coronary flow reserve -- DSVR, diastolic to systolic velocity ratio -- NCA, normal coronary artery; aortic stiffness -- coronary artery disease -- coronary circulation; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2005.067934
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To investigate the relation between aortic stiffness and coronary flow reserve (CFR) in patients with coronary artery disease (CAD). Design: Observational study. Setting: Coronary care unit of a primary care hospital. Patients: 192 consecutive patients who underwent coronary angiography. Main outcome measure: Brachial-ankle pulse wave velocity (ba-PWV), CFR, and severity of CAD. Results: According to the angiographic findings, patients were divided into four subgroups: patients without significant stenosis (normal coronary artery (NCA) group, n = 28) and those with one vessel disease (1VD group, n = 92), two vessel disease (2VD group, n = 50), or three vessel disease (3VD group, n = 22). ba-PWV increased with the number of diseased vessels and was significantly correlated with the number of diseased vessels (NCA group v 1VD group v 2VD group v 3VD group: 1481 (252) v 1505 (278) v 1577 (266) v 1727 (347) cm/s, p < 0.001). CFR had a significant negative correlation with ba-PWV ( r = −0.45, p < 0.0001). The diastolic to systolic velocity ratio obtained in 45 patients also was significantly correlated with ba-PWV ( r = −0.35, p < 0.05). Multiple regression analysis showed that ba-PWV was an independent determinant of CFR (p < 0.01). Conclusions: Coronary flow is altered with aortic stiffening in patients with CAD. These results suggest one possible mechanism for recent reports that aortic stiffness is a key cardiovascular risk factor.