Increased plasma concentrations of interleukin-18 in acute coronary syndromes. Issue 5 (1st November 2002)

• Record Type: Journal Article
• Authors: Mallat, Z; Henry, P; Fressonnet, R; Alouani, S; Scoazec, A; Beaufils, P; Chvatchko, Y; Tedgui, A
• Is Part Of: Heart. Volume 88:Issue 5(2002)
• Page Start: 467
• Page End: 469
• Publication Date: 2002-11-01
• Subjects: myocardial infarction -- acute coronary syndromes -- inflammation -- interleukin-18 -- IL-18; ELISA, enzyme linked immunosorbent assay -- IL, interleukin -- MI, myocardial infarction; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heart.88.5.467
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To examine the relation between plasma concentrations of interleukin-18 (IL-18), the interferon γ inducing factor, and clinical instability of coronary artery disease. Design and setting: Observational study in a university hospital. Patients: 11 patients with unstable angina and negative troponin I, 21 patients with acute non-Q wave myocardial infarction (MI), 21 patients with acute Q wave MI, 9 patients with stable angina, and 11 controls. Main outcome measures: Plasma IL-18 concentrations and their relation to clinical instability and myocardial dysfunction. Results: Plasma concentrations of IL-18 were significantly increased in the unstable angina and MI groups in comparison with the stable angina and control groups (p < 0.01). No difference in IL-18 concentrations were found between patients with unstable angina, patients with non-Q wave MI, and patients with Q wave MI. Plasma IL-18 concentrations significantly correlated with decreased left ventricular ejection fraction (p = 0.01). Conclusions: Plasma IL-18 concentrations are increased in patients with acute coronary syndromes and correlate with the severity of myocardial dysfunction.