BAS/BSCR47 Quantitative metabolic profiling of subclinical atherosclerosis by serum NMR metabonomics. Issue 17 (26th August 2010)

• Record Type: Journal Article
• Authors: Würtz, P; Soininen, P; Kangas, A J; Magnussen, C G; Raiko, J H; Mäkinen, V P; Groop, P H; Thomson, R; Savolainen, M J; Juonala, M; Viikari, J; Kähänen, M; Lehtimäki, T; Raitakari, O T; Ala-Korpela, M
• Is Part Of: Heart. Volume 96:Issue 17(2010)
• Page Start: e26
• Page End: e26
• Publication Date: 2010-08-26
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.205781.58
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To determine associations of systemic metabolites with subclinical atherosclerosis. Methods: 4407 serum samples were measured by nuclear magnetic resonance (NMR) spectroscopy from the Cardiovascular Risk in Young Finns Study, and carotid intima-media thickness (IMT) was assessed by ultrasound. Numerous lipoprotein lipids subclasses as well as low-molecular-weight metabolites were quantified from the NMR data. Results: In these young adults (aged 24–45 years) data-driven analysis using self-organising maps showed distinct metabolic phenotypes associated with elevated IMT. The phenotypes were characterised by varying combinations of metabolic disturbances including elevated very-low-density lipoprotin (VLDL) and LDL subclasses, but also several low-molecular-weight metabolites. Results for 6-year incidence of high carotid IMT and IMT progression as shown by discrimination and reclassification will also be discussed. Conclusion: The study showed different metabolic phenotypes inherently associated with subclinical atherosclerosis. Prediction of subclinical atherosclerosis was improved by comprehensive metabolic profiling. The findings substantiate developments towards the use of multi-metabolic risk phenotypes in cardiovascular risk assessment.