Viruses and non-allergen environmental triggers in asthma. (27th July 2019)

• Record Type: Journal Article
• Authors: Chau-Etchepare, Florence; Hoerger, Joshua L; Kuhn, Brooks T; Zeki, Amir A; Haczku, Angela; Louie, Samuel; Kenyon, Nicholas J; Davis, Cristina E; Schivo, Michael
• Is Part Of: Journal of investigative medicine. Volume 67:Number 7(2019)
• Page Start: 1029
• Page End: 1041
• Publication Date: 2019-07-27
• Subjects: asthma -- tobacco; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2019-001000
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM2.5 ), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms.