Propofol combined with lorazepam for severe poly substance misuse and withdrawal states in intensive care unit: a case series and review. Issue 5 (25th August 2004)

• Record Type: Journal Article
• Authors: Subramaniam, K; Gowda, R M; Jani, K; Zewedie, W; Ute, R
• Is Part Of: Emergency medicine journal. Volume 21:Issue 5(2004)
• Page Start: 632
• Page End: 634
• Publication Date: 2004-08-25
• Subjects: ICU, intensive care unit -- DT, delirium tremens; polysubstance misuse -- propofol -- lorazepam -- withdrawal syndromes; Emergency medicine -- Periodicals; 616.02505
• DOI: 10.1136/emj.2003.007526
• Languages: English
• ISSNs: 1472-0205

Abstract

Abstract : A safe, rapid, and effective way to detoxify patients from substance misuse is important in facilitating further treatment of their psychiatric or substance use disorder. This paper discusses the treatment of acute withdrawal from polysubstance misuse in three patients in the intensive care unit setting using combined sedation with a benzodiazepine, lorazepam, and a general anaesthetic, propofol. Lorazepam alone was not effective in massive doses in these cases. The advantages and mechanism of action of using multiple agents to control refractory symptoms is discussed.