Polymorphisms in the HBB gene relate to individual cardiorespiratory adaptation in response to endurance training. Issue 12 (21st September 2006)

• Record Type: Journal Article
• Authors: He, Z; Hu, Y; Feng, L; Lu, Y; Liu, G; Xi, Y; Wen, L; Xu, X; Xu, K
• Is Part Of: British journal of sports medicine. Volume 40:Issue 12(2006)
• Page Start: 998
• Page End: 1002
• Publication Date: 2006-09-21
• Subjects: ATP, adenosine 5′-triphosphate -- LBM, lean body mass -- RER, respiratory exchange ratio -- TBM, total body mass -- UTR, untranslated region; haplotype -- polymorphism -- running economy -- training -- VO2max; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2006.030866
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Objective: The crucial role of haemoglobin in endurance performance has been well documented. We examined whether polymorphisms in the HBB gene modified aerobic capacity. Methods: 102 recruits were trained by running 5000 m three times per week for 18 weeks. Exercise intensity progressively increased from an initial heart rate corresponding to 95% of the individual baseline ventilatory threshold during the first 10 weeks to 105% during the last 8 weeks. The phenotypes measured were running economy and VO2 max. Running economy was determined by measuring submaximal VO2 for 5 min at a constant running speed of 12 km·h −1 and VO2 max was obtained during an incremental test to exhaustion. Genomic DNA was extracted from white cells of peripheral blood and the −551C/T, intron2, +16C/G and +340 A/T genotypes were examined relative to the TAA site variants by PCR-RFLP. Results: Genotype distributions were in Hardy-Weinberg equilibrium at three loci. None of the running economy and VO2 max-related traits were associated with the three polymorphisms or haplotypes at baseline, while the training response of running economy was associated with −551C/T and intron2, +16C/G polymorphisms. Subjects homozygous for intron2, +16C/C or −551C/C had decreased oxygen cost of running compared to the other individuals. Discussion: It was concluded that the −551C/C or intron2, +16C/C genotype might explain part of the individual variation in the cardiorespiratory adaptation to endurance training.