Ectopic crypt foci in conventional and serrated colorectal polyps. Issue 12 (8th June 2016)

• Record Type: Journal Article
• Authors: Väyrynen, Sara A; Väyrynen, Juha P; Klintrup, Kai; Mäkelä, Jyrki; Tuomisto, Anne; Mäkinen, Markus J
• Is Part Of: Journal of clinical pathology. Volume 69:Issue 12(2016)
• Page Start: 1063
• Page End: 1069
• Publication Date: 2016-06-08
• Subjects: COLORECTAL CANCER -- HISTOPATHOLOGY -- IMMUNOHISTOCHEMISTRY; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2015-203593
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Aims: Despite almost pathognomonic status of ectopic crypt foci (ECF) in the diagnosis of traditional serrated adenoma (TSA), there are few systematic studies on their prevalence in other types of colon polyps or in adenomas adjacent to colorectal cancer (CRC). Methods: We calculated ECF in all the polyps (n=922) removed in the colonoscopy in Oulu University Hospital in 2001. Moreover, to study ECF in precursor lesions next to CRCs, we re-examined a previously described cohort of 148 CRCs. Results: ECF were seen in 53 (5.7%) polyps representing 28 (6.5%) tubular adenomas (TAs), 14 (53.8%) tubulovillous adenomas (TVAs), 2 (100.0%) villous adenomas (VAs) and 9 (100.0%) TSAs. In all TSAs and VAs, the density of ECF was higher than in TVAs and TAs. An adjacent precursor lesion was recognised in 28 of 148 (18.9%) CRCs. Twenty-four (85.7%) of these contained ECF. Conclusions: ECF can most frequently be observed in TSAs but also in many TVAs, VAs and TAs, reflecting a histological overlap between serrated and conventional polyps. Especially, precursor lesions adjacent to CRC frequently contain ECF.