Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins. Issue 6 (June 1982)

• Record Type: Journal Article
• Authors: Konturek, S J; Brzozowski, T; Piastucki, I; Radecki, T
• Is Part Of: Gut. Volume 23:Issue 6(1982)
• Page Start: 536
• Page End: 540
• Publication Date: 1982-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.23.6.536
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Paracetamol or sodium salicylate given intragastrically 30 minutes before the administration of absolute ethanol or acidified aspirin dose-dependently reduced the formation of mucosal lesions. The generation of gastric mucosal prostaglandin-like activity increased with ethanol and was completely suppressed by acidified aspirin. Paracetamol or sodium salicylate given alone increased the generation of mucosal prostaglandin-like material. Indomethacin, the prostaglandin synthesis inhibitor, suppressed this effect and inhibited the protective influence of paracetamol or sodium salicylate on the production of gastric lesions.