Clinical implications of E-cadherin associated hereditary diffuse gastric cancer. Issue 6 (11th May 2004)

• Record Type: Journal Article
• Authors: Fitzgerald, R C; Caldas, C
• Is Part Of: Gut. Volume 53:Issue 6(2004)
• Page Start: 775
• Page End: 778
• Publication Date: 2004-05-11
• Subjects: E-cadherin -- gastric cancer -- gastrectomy -- genetic susceptibility -- screening; HDGC, hereditary diffuse gastric cancer; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.2003.022061
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).