Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review. (3rd July 2021)

• Record Type: Journal Article
• Authors: Gvoic, Marija; Vukmirovic, Sasa; Al-Salami, Hani; Mooranian, Armin; Mikov, Momir; Stankov, Karmen
• Is Part Of: Pharmaceutical development and technology. Volume 26:Number 6(2021)
• Page Start: 617
• Page End: 633
• Publication Date: 2021-07-03
• Subjects: the blood–brain barrier -- the blood–tumor barrier -- bile acids -- nanoparticle -- CNS antitumor drugs delivery; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2021.1916032
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: Despite a relatively low prevalence of primary brain tumors, they continuously attract scientific interest because of the complexity of their treatment due to their location behind the blood–brain barrier. The main challenge in treatment of brain tumors is not the efficacy of the drugs, per se, but the low efficiency of drug delivery to malignant cells. At the core of the problem is the complex structure of the blood–brain barrier. Nowadays, there is evidence supporting the claim that bile acids have the ability to cross the blood–brain barrier. That ability can be exploited by taking a part in novel drug carrier designs. Bile acids represent a drug carrier system as a part of a mixed micelle composition, bilosomes and conjugates with various drugs. This review discusses the current knowledge related to bile acid molecules as drug penetration modifying agents, with the focus on central nervous system antitumor drug delivery. Graphical Abstract: UF0001