In vitro anti-enteroviral activity of stilbenoids isolated from the leaves of Macaranga barteri. Issue 11 (3rd June 2021)

• Record Type: Journal Article
• Authors: Segun, Peter A.; Ogbole, Omonike O.; Akinleye, Toluwanimi E.; Faleye, Temitope O. C.; Adeniji, Adekunle J.
• Is Part Of: Natural product research. Volume 35:Issue 11(2021)
• Page Start: 1909
• Page End: 1913
• Publication Date: 2021-06-03
• Subjects: Antiviral -- cytopathic reduction assay -- echovirus -- Macaranga barteri -- stilbenes; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1644505
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The anti-enteroviral activity of three stilbenoids isolated from the leaves of Macaranga barteri was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (2 ), schweinfurthin G (3 ) and mappain (1 ) elicited antiviral activity on E19 with IC50 values of 0.0036 nM, 0.018 nM and 0.24 µM, respectively. Vedelianin (2 ) showed the best selectivity profile amongst the isolated compounds with selectivity index values of 31 and 216 against E7 and E19, respectively. It is possible these compounds may be responsible for the traditional use of Macaranga barteri in the treatment of viral infections. Graphical Abstract: UF0001