Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics. (21st April 2021)

• Record Type: Journal Article
• Authors: Ajoolabady, Amir; Aslkhodapasandhokmabad, Hamid; Henninger, Nils; Demillard, Laurie J.; Nikanfar, Masoud; Nourazarian, Alireza; Ren, Jun
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 48:Number 7(2021)
• Page Start: 943
• Page End: 953
• Publication Date: 2021-04-21
• Subjects: Alzheimer's disease -- autophagy -- Huntington's disease -- neurodegenerative disease -- Parkinson's disease; Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.13500
• Languages: English
• ISSNs: 0305-1870

Abstract

Abstract: Many neurodegenerative diseases are associated with pathological aggregation of proteins in neurons. Autophagy is a natural self‐cannibalization process that can act as a powerful mechanism to remove aged and damaged organelles as well as protein aggregates. It has been shown that promoting autophagy can attenuate or delay neurodegeneration by removing protein aggregates. In this paper, we will review the role of autophagy in Alzheimer's disease (AD), Parkinson's Disease (PD), and Huntington's Disease (HD) and discuss opportunities and challenges of targeting autophagy as a potential therapeutic avenue for treatment of these common neurodegenerative diseases. Abstract : Holistic strategies for targeting autophagy in the management of neurodegenerative diseases. Natural autophagy inducers manipulate autophagy regulators via various mechanisms, leading to basal autophagy induction.