Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Issue 1 (January 1986)

• Record Type: Journal Article
• Authors: Mitchell, T J; Ketley, J M; Haslam, S C; Stephen, J; Burdon, D W; Candy, D C; Daniel, R
• Is Part Of: Gut. Volume 27:Issue 1(1986)
• Page Start: 78
• Page End: 85
• Publication Date: 1986-01
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.27.1.78
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.