Relation between GB virus C/hepatitis G virus and fulminant hepatic failure may be secondary to treatment with contaminated blood and/or blood products. Issue 2 (1st February 1999)

• Record Type: Journal Article
• Authors: Halasz, R; Barkholt, L; Lara, C; Hultgren, C; Ando, Y; Broomé, U; Fischler, B; Nemeth, A; Ericzon, B-G; Sönnerborg, A; Sällberg, M
• Is Part Of: Gut. Volume 44:Issue 2(1999)
• Page Start: 274
• Page End: 278
• Publication Date: 1999-02-01
• Subjects: fulminant hepatitis -- GB virus C -- hepatitis G virus -- RNA -- antibodies -- liver; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.44.2.274
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. Aims: To retrospectively investigate the possible relation between the presence of GBV-C markers (RNA or antibodies to the GBV-C envelope 2 (E2) glycoprotein) and FHF. Methods: The presence of GBV-C RNA was determined in serum samples from 58 patients diagnosed with FHF using a reverse transcriptase polymerase chain reaction. Amplified genetic fragments were directly sequenced by the dideoxy chain termination method. Antibodies to GBV-C in serum samples were detected by enzyme immunoassay based on a recombinant GBV-C E2 protein. Results: Nine (16%) patients with FHF had GBV-C RNA and 14 (24%) had GBV-C E2 antibodies, which are higher frequencies than in healthy subjects (p<0.01 and p<0.05 respectively). Seven of ten patients with GBV-C markers during FHF tested negative for these markers before therapy with blood and/or blood products. Sequence analysis of the GBV-C NS3 region fragments of six FHF patients showed no common sequence pattern or motif. Conclusions: The frequencies of both GBV-C RNA and antibodies are higher in patients with FHF than in healthy subjects. However, these increased frequencies may in many cases be explained by the use of contaminated blood and/or blood products given as therapy.