Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Issue 10 (22nd September 2003)

• Record Type: Journal Article
• Authors: Buzio, L; De Palma, G; Mozzoni, P; Tondel, M; Buzio, C; Franchini, I; Axelson, O; Mutti, A
• Is Part Of: Occupational and environmental medicine. Volume 60:Issue 10(2003)
• Page Start: 789
• Page End: 793
• Publication Date: 2003-09-22
• Subjects: occupational exposure -- genetic susceptibility -- kidney cancer; GSH, glutathione -- GST, glutathione S-transferase -- OR, odds ratio -- PCR, polymerase chain reaction -- RCC, renal cell cancer -- TRI, trichloroethylene; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oem.60.10.789
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Aims: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 ( GSTM1 and GSTT1 ) in renal cell cancer (RCC). Methods: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 ( GSTM1 ) and T1-1 ( GSTT1 ) were investigated by PCR; occupational history was collected by a structured questionnaire. Results: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73; 95% CI 0.91 to 8.22 v 1.14; 95% CI 0.46 to 2.82) or pesticides (OR 3.46; 95% CI 1.12 to 10.74 v 1.59; 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. Conclusions: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.