Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist. Issue 7 (July 1981)

• Record Type: Journal Article
• Authors: McIsaac, R L; Johnston, B J; Fielding, L P
• Is Part Of: Gut. Volume 22:Issue 7(1981)
• Page Start: 529
• Page End: 533
• Publication Date: 1981-07
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.22.7.529
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The effect of impromidine, a new histamine-H2-receptor agonist, on gastric mucosal blood flow (neutral red clearance) and acid secretion was studied in nine volunteers. Impromidine stimulated a dose-dependent increase in neutral red clearance and acid secretion. Simultaneous cimetidine in three doses caused a parallel shift to the right for both acid output and clearance with unchanged maxima compatible with simple surmountable antagonism. There were small cardiovascular changes: an increased heart rate with a decreased diastolic pressure during infusion of impromidine. These changes were antagonised by cimetidine.