Piroxicam induced submassive necrosis of the liver. Issue 10 (October 1992)

• Record Type: Journal Article
• Authors: Paterson, D; Kerlin, P; Walker, N; Lynch, S; Strong, R
• Is Part Of: Gut. Volume 33:Issue 10(1992)
• Page Start: 1436
• Page End: 1438
• Publication Date: 1992-10
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.33.10.1436
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Several widely used non-steroidal anti-inflammatory drugs have been reported as causing severe hepatitis. Three cases of severe acute hepatitis have been reported in association with piroxicam. A fatal submassive necrosis that occurred in a 68 year old lady who had received piroxicam for 15 months is described. A 48 year old man who developed submassive hepatic necrosis six weeks after beginning piroxicam but was successfully treated with orthotopic liver transplantation is also reported. Piroxicam may induce submassive necrosis of the liver, probably as an idiosyncratic reaction.