Enhanced intestinal glucose and alanine transport in cystic fibrosis. Issue 7 (July 1990)

• Record Type: Journal Article
• Authors: Baxter, P; Goldhill, J; Hardcastle, J; Hardcastle, P T; Taylor, C J
• Is Part Of: Gut. Volume 31:Issue 7(1990)
• Page Start: 817
• Page End: 820
• Publication Date: 1990-07
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.31.7.817
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.