The IL23 axis plays a key role in the pathogenesis of IBD. Issue 10 (13th September 2007)

• Record Type: Journal Article
• Authors: McGovern, Dermot; Powrie, Fiona
• Is Part Of: Gut. Volume 56:Issue 10(2007)
• Page Start: 1333
• Page End: 1336
• Publication Date: 2007-09-13
• Subjects: DC, dendritic cell -- IBD, irritable bowel disease -- IFNγ, interferon γ -- IL, interleukin -- IL23R, interleukin 23 receptor -- SNP, single-nucleotide polymorphism -- TGFβ, transforming growth factor β -- Th, T helper -- TNFα, tumour necrosis factor α; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.2006.115402
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.