Ameliorative effects of tropisetron on liver injury in streptozotocin-induced diabetic rats. (4th July 2021)

• Record Type: Journal Article
• Authors: Gholizadeh-Ghaleh Aziz, Shiva; Naderi, Roya; Mahmodian, Nima
• Is Part Of: Archives of physiology and biochemistry. Volume 127:Number 4(2021)
• Page Start: 367
• Page End: 372
• Publication Date: 2021-07-04
• Subjects: Diabetes -- tropisetron -- glibenclamide -- lipid profile -- liver; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2019.1640743
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: This study aimed to evaluate the effect of tropisetron on liver injury induced by diabetes. Thirty-five male Wistar rats were assigned to five groups ( n = 7): control (C), tropisetron (T), diabetic (D), diabetic + tropisetron (D + T) and diabetic + glibenclamide (D + G). Diabetic rats were treated with tropisetron (3 mg/kg body weight/day) or glibenclamide (1 mg/kg/day) for two weeks. Liver from diabetic rats exhibited a significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol (Chol), triglycerides (TG), low-density lipoprotein (LDL), and atherogenic index, and a significant decrease in liver glycogen, serum albumin and high-density lipoprotein. Treatment with tropisetron significantly abrogated diabetes-induced perturbation in these parameters. These effects were equipotent with glibenclamide, suggesting that tropisetron treatment is associated with a hepatoprotective effect against diabetic injury. Therefore, the results of this study manifested the significance of using tropisetron as a promising remedial agent to improve diabetic complications.