Prevalence and Its Correlation with Sustained Opioid Use in Korea: A Group-Based Trajectory Analysis. Issue 3 (27th May 2021)

• Record Type: Journal Article
• Authors: Yoon, Dongwon; Lee, Hyesung; Baek, Yeon-Hee; Jeong, Han Eol; Shin, Ju-Young
• Is Part Of: Journal of psychoactive drugs. Volume 53:Issue 3(2021)
• Page Start: 224
• Page End: 229
• Publication Date: 2021-05-27
• Subjects: Group-based trajectory modeling -- trajectory analysis -- opioid analgesics -- opioid adherence; Hallucinogenic drugs -- Periodicals; Drug abuse -- Periodicals; Hallucinogens -- Periodicals; Psychotropic Drugs -- Periodicals; Drogues -- Périodiques; Hallucinogènes -- Périodiques; Electronic journals; 616.86
• DOI: 10.1080/02791072.2020.1856456
• Languages: English
• ISSNs: 0279-1072

Abstract

ABSTRACT: Long-term use of opioid analgesics can lead to addiction and opioid-related death. We aimed to present the pattern of long-term opioid utilization and identify factors associated with it by using group-based trajectory modeling. We used the nationwide health insurance claims database from 2009 to 2013. Multinomial logistic regression was conducted to estimate the adjusted odds ratio (aOR) and its 95% confidence intervals (CI) for the risk of sustained opioid use associated with various clinical factors. Among 15, 327 patients prescribed with opioids, three trajectories were identified: high-sustained users (4.6%, n = 713), early discontinuation (84.2%, n = 12, 916), and slow discontinuation (11.2%, n = 1, 698). A higher proportion of women (72.8% vs. 58.4%) and elderly patients (55.9% vs. 22.1%) were found in the high-sustained users than the early discontinuation group. Depression (aOR 3.55, 95% CI 1.99–6.35) and epilepsy (aOR 10.12, CI 4.72–21.67) were the two highest comorbidities associated with sustained opioid use in the high-sustained users when compared to the early discontinuation group. Among chronic non-cancer patients, 4.6% were prescribed opioids consistently. Both healthcare providers and patients should be aware of the factors associated with sustained opioid use when prescribing it to patients with mental-related conditions, and its consequent adverse events should be carefully monitored.