(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities. Issue 15 (3rd August 2021)

• Record Type: Journal Article
• Authors: Promchai, Thanika; Thaima, Thanaphat; Rattanajak, Roonglawan; Kamchonwongpaisan, Sumalee; Pyne, Stephen G.; Limtharakul, Thunwadee
• Is Part Of: Natural product research. Volume 35:Issue 15(2021)
• Page Start: 2476
• Page End: 2481
• Publication Date: 2021-08-03
• Subjects: Anomianthus dulcis -- farnesylindole -- antiplasmodial activities -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1679139
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new farnesylindole, ( R )-3-(8'-hydroxyfarnesyl)-indole (1 ), as a scalemic mixture (33% ee ) along with nine known compounds (2 -10 ), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis . All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells. Graphical Abstract: