Perovskanol, a new sesquiterpenoid with an unprecedented skeleton from Perovskia Abrotanoides. Issue 15 (3rd August 2021)

• Record Type: Journal Article
• Authors: Karimzadeh, Seyedeh Masoomeh; Moridi Farimani, Mahdi; Amiri, Mohammad Sadegh; Tabefam, Marzieh; Alilou, Mostafa; Stuppner, Hermann
• Is Part Of: Natural product research. Volume 35:Issue 15(2021)
• Page Start: 2515
• Page End: 2519
• Publication Date: 2021-08-03
• Subjects: Lamiaceae -- Perovskia abrotanoides -- sesquiterpenoid -- perovskanol; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1684280
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation of the aerial parts of Perovskia abrotanoides (Lamiaceae) by normal phase column chromatography resulted in the isolation of perovskanol (1 ), a novel sesquiterpenoid possessing a 5/7/5 fused carbon ring skeleton. The structure of 1 was established by comprehensive spectroscopic data analysis including 1 D and 2 D NMR and HRESIMS. The antiprotozoal activity of compound 1 was evaluated against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, Plasmodium falciparum and no promising activities were shown against all parasite tested. Graphical Abstract: