Hydroxyl radical is a significant player in oxidative DNA damage in vivo. (15th June 2021)

• Record Type: Journal Article
• Authors: Halliwell, Barry; Adhikary, Amitava; Dingfelder, Michael; Dizdaroglu, Miral
• Is Part Of: Chemical Society reviews. Volume 50:Number 15(2021)
• Page Start: 8355
• Page End: 8360
• Publication Date: 2021-06-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cs00044f
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Schematic representation of the important chemical reactions involved in reactive oxygen species-mediated DNA damage. Abstract : Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO3 ˙ − ) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo .