Catalyst free N-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2 using NaBH4. Issue 41 (27th July 2021)

• Record Type: Journal Article
• Authors: Kumar, Arun; Sharma, Pankaj; Sharma, Nidhi; Kumar, Yashwant; Mahajan, Dinesh
• Is Part Of: RSC advances. Volume 11:Issue 41(2021)
• Page Start: 25777
• Page End: 25787
• Publication Date: 2021-07-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra04848a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Herein, we report a sustainable approach for N -formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas. Abstract : Herein, we report a sustainable approach for N -formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2 with sodium borohydride generates formoxy borohydride species in situ, as confirmed by 1 H and 11 B NMR spectroscopy. The in situ formation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of the N -formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2 with amine leading to N -formylation of amines.