A fluorescence-activatable tumor-reporting probe for precise photodynamic therapy. Issue 29 (13th July 2021)

• Record Type: Journal Article
• Authors: Li, Jian; Wang, Tingting; Jiang, Feng; Hong, Zhangyong; Su, Xinhui; Li, Shuang; Han, Shoufa
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 29(2021)
• Page Start: 5829
• Page End: 5836
• Publication Date: 2021-07-13
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00704a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Approaches that could enable precise photodynamic therapy (PDT) are of therapeutic potential. Abstract : Approaches that could enable precise photodynamic therapy (PDT) are of therapeutic potential. We herein report a trifunctional probe (Glu-RdEB ) that could be activated to generate fluorescent rhodamine species to pinpoint tumor foci. The probe contains a γ-glutaminyl moiety cleavable to γ-glutamyl transpeptidase (GGT) overexpressed in multiple tumors, an entity of an ENBS photosensitizer for PDT, and an entity of rhodamine fluorescently quenched by ENBS. Upon activation by tumor-associated GGT, the probe releases highly fluorescent rhodamine that is selectively confined in tumors whereby light irradiation leads to effective tumor regression in mice. These results indicate the feasibility of a fluorescently quenched dye–photosensitizer pair to yield tumor-activatable fluorescence to direct PDT.