RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling. Issue 61 (8th July 2021)

• Record Type: Journal Article
• Authors: Jeancolas, Cyrille; Matsubara, Yoshiya J.; Vybornyi, Mykhailo; Lambert, Camille N.; Blokhuis, Alex; Alline, Thomas; Griffiths, Andrew D.; Ameta, Sandeep; Krishna, Sandeep; Nghe, Philippe
• Is Part Of: Chemical communications. Volume 57:Issue 61(2021)
• Page Start: 7517
• Page End: 7520
• Publication Date: 2021-07-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02290c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The integration of self-reproduction and diversification mechanisms in RNA reaction networks paves the way for experimental tests of prebiotic evolution. Abstract : We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.