Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives. Issue 41 (22nd July 2021)

• Record Type: Journal Article
• Authors: Bellina, Fabio; Biagetti, Matteo; Guariento, Sara; Lessi, Marco; Fausti, Mattia; Ronchi, Paolo; Rosadoni, Elisabetta
• Is Part Of: RSC advances. Volume 11:Issue 41(2021)
• Page Start: 25504
• Page End: 25509
• Publication Date: 2021-07-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra05303e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The regioselective synthesis of 2-alkynyl(benz)imidazoles was successfully achieved by Pd(ii )/Ag(i )-mediated dehydrogenative alkynylation of the corresponding (benz)imidazoles with terminal alkynes in an open vessel. Abstract : A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag2 CO3 as the oxidant and Pd(OAc)2 as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.