The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. (September 2021)

• Record Type: Journal Article
• Authors: Annunziata, Giuseppe; Sureda, Antoni; Orhan, Ilkay Erdogan; Battino, Maurizio; Arnone, Angela; Jiménez-García, Manuel; Capó, Xavier; Cabot, Joan; Sanadgol, Nima; Giampieri, Francesca; Tenore, Gian Carlo; Kashani, Hamid Reza Khayat; Silva, Ana Sanches; Habtemariam, Solomon; Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 128(2021)
• Page Start: 437
• Page End: 453
• Publication Date: 2021-09
• Subjects: neurodegeneration -- aging-related cognitive decline -- innate immunity -- polyphenols -- nutraceutical; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2021.07.004
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: There is a complex interplay between gut microbiota, nervous and immune system. This relationship leads to introduce the concept of the gut-brain-immune axis. Evidence reported the role of polyphenols in modulating the gut-brain-immune axis. Polyphenols may be effective in management of gut-brain-immune axis-related diseases. Abstract: Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.