From observing to controlling: Inducible control of organelle dynamics and interactions. (August 2021)

• Record Type: Journal Article
• Authors: Passmore, Josiah B.; Nijenhuis, Wilco; Kapitein, Lukas C.
• Is Part Of: Current opinion in cell biology. Volume 71(2021)
• Page Start: 69
• Page End: 76
• Publication Date: 2021-08
• Subjects: Organelles -- Motor proteins -- Optogenetics -- Chemogenetics -- Organelle contact sites.; Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2021.02.002
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract: The dynamics and interactions of cellular organelles underlie many aspects of cellular functioning. Until recently, assessment of organelle dynamics has been primarily observational or required whole-cell perturbations to assess the implications of altered organelle motility and positioning. However, thanks to recently developed and optimized intervention strategies, we now have the ability to control organelles in their unperturbed state, altering organelle positioning, membrane trafficking pathways, as well as organelle interactions. This can be performed both globally and locally, giving fine control over the range, reversibility, and extent of organelle dynamics. Here, we describe how these tools are currently used for controlling organelles and give insight into the exciting future of this emerging field.